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Model Labs

Boltz Community

Open-source community behind the Boltz biomolecular structure and affinity models.

Structure prediction1 model

Models on Rafflesia

Boltz-2

activeMIT
boltz-community/boltz/2/fold

Predict biomolecular complex structures and optional binding-affinity measurements through Rafflesia's durable prediction jobs in explicit query-only alignment mode.

Structure predictionprotein_sequence + dna_sequence + rna_sequence + ligand → structure_artifact + confidence_measurements + affinity_measurements + msa_object
$0.10 / prediction

About

Boltz is an open-source line of biomolecular foundation models that predict complex structures and binding affinity. The models originated with researchers at MIT's Jameel Clinic and are developed openly with a broader community.

On Rafflesia, Boltz-2 is served for production use via the runs API, covering protein, DNA, RNA, and ligand inputs with optional affinity outputs.

Use these models

Every endpoint speaks the same run lifecycle: POST the endpoint id and a typed input, get a run back with outputs, provenance, and measured billing.

run.sh
# one run lifecycle, every endpoint
curl https://api.rafflesia.ai/v1/runs \
  -H "Authorization: Bearer $RAFFLESIA_API_KEY" \
  -H "Content-Type: application/json" \
  -d '{
        "endpoint": "boltz-community/boltz/2/fold",
        "input": { "sequence": "MKTAYIAK..." }
      }'
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